Edit: Small clip: Tourney6 by myself:
http://www.zippyvideos.com/3050113831794546/aga/
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The biggest difference to Q3 I can speak of is the slight feeling, that you are running on a giant trampoline in a low-gravity-environment.

When strafe-jumping, speed is not gained as quickly as in Q3. At least when adapting your tried and tested strafe-jumping technique from Q3. It is at least as fast as Q3.

It feels a little less controllable (rocket jumps felt strange, etc...), but I think it's too early to judge on this. I think there is less air-control than in Q3V - I could not make it to the center jump pad on DM17.

Weapon feeling is excellent. It is even better than Q3 because you get the impression the player is actually holding something. I think this is because of a slight delay between mouse-action and weapon-reaction, suggesting that a mechanical device is handled, triggered by the mouse. Very neat. Well done.

Overall impression: Q4 Multiplayer OWNS!! It sports the same pedal-to-the-metal directness, that has made me a Q3 addict. It will probably appeal even to the most hardcore skill gamer and is bound to shake up the Quake community.

Excuse me, I need to figure out some nice rocket-through-tele shots.
Muhauhauha fear me!